N. Bhavatharani
SRC Diabetes Centre, IndiaPresentation Title:
Primordial prevention of Diabetes
Abstract
The prevalence of diabetes is increasing globally. The Lifestyle modification and drug intervention are likely to delay or postpone the development of overt diabetes in persons diagnosed to have impaired glucose tolerance. This is a post primary prevention strategy. The primordial prevention is more important as this effort is likely to reverse or halt the epidemic of disease. What. is needed is primordial prevention of diabetes That is disease should not develop. The body's susceptibility to “lifestyle" disease(s) was programmed intrauterine (David Barker}. Women with a history of Gestational Diabetes Mellitus (GDM) are at increased risk of future diabetes, predominantly Type 2 DM, as are their children. Transgenerational Transmission occurs. There is evidence that a fetus exposed to high blood sugar of > 110 (Fetal renal threshold) in the intrauterine period may have programming of the pancreas by 11 weeks which results in beta cell impairment. This may later result in insulin resistance and its severe metabolic implications. First Time National Institute of Health (NIH) stated that HbA1c 5.3% (2hr PPBS - 110 mg/dl) at the 10th week of pregnancy may help to identify women at risk of GDM and its consequence “Fetal origin of Adult Disease”. The concept is based on, the prediction of GDM by a simple test of 2 hours postprandial blood sugar (PPBS) before 10 weeks in pregnancy will guide clinicians to start intervention immediately for preventing the development gestational diabetes. This will prevent a huge burden of future NCDs like impaired glucose tolerance, diabetes, obesity hypertension, coronary artery disease, metabolic syndrome etc. in these patients
Biography
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