Carolina Bologna
Sea Hospital , ItalyTitle: Clinical Study on the Efficacy and Safety of Arginine Administered Orally in Association with Other Active Ingredients for the Prevention and Treatment of Sarcopenia in Patients with COVID-19-Related Pneumonia, Hospitalized in a Sub-Intensive Care Unit
Abstract
In order to evaluate the efficacy of oral supplementation with 3 g of arginine per day associated with creatine, L-carnitine, aspartic acid, magnesium, selenium and vitamins C and E (Argivit© Aesculapius Farmaceutici) in the prevention and treatment of sarcopenia in patients with COVID-19-related pneumonia, we conducted a parallel randomized study comparing it with standard therapy alone. Forty patients on standard therapy plus supplementation were compared with a control group of 40 patients, all hospitalized at the sub-intensive care unit of the Del Mare Hospital in Naples, with a clinical diagnosis of SARS-CoV-2 infection and COVID-19 pneumonia. Muscle strength was assessed with the handgrip test and muscle ultrasound. Arginine-supplemented patients had an average grip strength of 23.5 at the end of hospitalization compared with 22.5 in the untreated group with less reduction, showing statistical significance (p < 0.001). In the same way, the thickness of the vastus lateralis quadriceps femoris muscle measured at the end of hospitalization showed less reduction on ultrasound, with a higher average value in the group receiving treatment than in the group of patients without supplementation (p < 0.001). Upon discharge there was a 58.40% reduction in ventilation days in patients with arginine supplementation compared with the control group.
Biography
Carolina Bologna was born in Caserta, specialist in Geriatrics, medical director of Internal Medicine with a permanent contract since 16 July 2009 currently in service at the UOC General Medicine Ospedale del Mare in Naples. She completed a Degree in Medicine and Surgery at the Faculty of Medicine and Surgery of the Second University of Naples with a score of 110/110 with honors, the approval of the Commission and the recognition of the dignity of printing for the thesis. Qualification to practice as a doctor in the autumn session of 2003 with a vote of 90/90. Specialization in Geriatrics and Gerontology at the Second University of Naples with 50/50 cum laude PhD in Geriatric Pathophysiology – 23rd cycle – at the Second University of Naples University of Naples Federico II Specialization Course in Global Health Master II level in Psychogeriatrics obtained at La Sapienza University with 110\110 cum laude Advanced training course in Management and Clinical Governance for diabetes at the LIUC University of Varese Master II Level Hemostasis and Thrombosis at Federico II University of Naples Author of numerous national and international publications and university professor with annual assignments. He is mainly interested in nutrition, sarcopenia and cognitive deficits in the frail elderly patient.
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