Yousra Nasr
Ain Shams University, EgyptPresentation Title:
Proteus mirabilis in ICU patients: Prevalence, risk factors, and future expectations of bloodstream infections
Abstract
Background
Proteus mirabilis is an emerging but under-recognized cause of Bloodstream Infections (BSIs) in Intensive Care Unit (ICU) settings, where invasive procedures and immunocompromised states increase vulnerability. Despite its clinical importance, the epidemiology and risk factors associated with P. mirabilis BSIs remain poorly understood, especially in low- and middle-income countries.
Gap
Most existing studies generalize Gram-negative pathogens without isolating the specific impact of P. mirabilis in ICU populations. There is a lack of data on species, specific risk factors, infection sources, and outcome predictors.
Methodology
Methodology
A retrospective cross-sectional study was conducted on 30 adult ICU patients admitted between January and December 2024. Clinical, procedural, and microbiological data were extracted from electronic medical records. Statistical analysis and regression modeling (Linear, Ridge, and Lasso) were applied using SPSS and Python to identify significant predictors of ICU stay and infection risk.
Findings and conclusion
Proteus mirabilis was detected in 53.3% of patients, and 56.7% of infections are hospital-acquired. Central line use (60%), ventilator support (60%), and urinary catheterization (63.3%) were more frequent among infected individuals. Regression models identified central line placement (β=3.24), hospital-acquired infection (β=2.46), and diabetes (β=1.05) as major predictors of prolonged ICU stay. Lasso regression highlighted the device and related variables as the most robust predictors.
Biography
Yousra Nasr is a physician from Egypt with broad clinical training across internal medicine, surgery, and acute care. She graduated with honors from Ain Shams University, Cairo, in 2022, and has since gained experience through residency roles in Egypt and clinical attachments in the United Kingdom. She holds full registration with both the General Medical Council (UK) and the Egyptian Medical Syndicate and is pursuing the MRCP (UK). Alongside clinical practice, she has published in Cureus, contributed to audits and quality improvement projects, and teaches point-of-care ultrasound. Her career aims center on advancing patient care, education, and collaborative research.
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